Cell Senescence Entries for ATXN10

Cell Types
Mammary fibroblast
Cell Lines
HMF3A
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Rovillain et al. (2011) An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence. BMC Genomics 12(2)355 (PubMed)

ATXN10 Gene Information

HGNC symbol
ATXN10 
Aliases
E46L; FLJ37990; SCA10 
Common name
ataxin 10 
Entrez Id
25814
Description
This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016].

ATXN10 Ontologies

Gene Ontology
Process: GO:7399; nervous system development
GO:31175; neuron projection development
GO:60271; cilium assembly
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5615; extracellular space
GO:30425; dendrite
GO:48471; perinuclear region of cytoplasm
GO:43025; neuronal cell body
Function: GO:5515; protein binding
Hide GO terms

Homologs of ATXN10 in Model Organisms

Danio rerio
atxn10
Drosophila melanogaster
CG4975
Mus musculus
Atxn10
Rattus norvegicus
Atxn10

External links

OMIM
611150
Ensembl
ENSG00000130638
Entrez Gene
25814
UniGene
475125
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATXN10
GeneCards
ATXN10