Cell Senescence Entries for AURKA

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

AURKA Gene Information

HGNC symbol
AURKA 
Aliases
AIK; ARK1; AurA; BTAK; PPP1R47; STK15; STK6; STK7 
Common name
aurora kinase A 
Entrez Id
6790
Description
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

AURKA Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division
GO:18105; peptidyl-serine phosphorylation
GO:30030; cell projection organization
GO:10629; negative regulation of gene expression
GO:7098; centrosome cycle
GO:226; microtubule cytoskeleton organization
GO:7052; mitotic spindle organization
GO:278; mitotic cell cycle
And 27 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5814; centriole
GO:5929; cilium
GO:5856; cytoskeleton
GO:42995; cell projection
GO:5813; centrosome
GO:5874; microtubule
GO:43005; neuron projection
And 17 more GO terms
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:19901; protein kinase binding
GO:35174; histone serine kinase activity
And 3 more GO terms
Show all GO terms

Homologs of AURKA in Model Organisms

Danio rerio
aurka
Mus musculus
Aurka
Rattus norvegicus
Aurka

In other databases

CellAge gene expression
  • This gene is present as AURKA

External links

OMIM
603072
Ensembl
ENSG00000087586
Entrez Gene
6790
UniGene
250822
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AURKA
GeneCards
AURKA