The AXL gene and its putative association with human ageing

Cell Senescence Entries for AXL

Cell Types: Embryonic kidney, Lung fibroblast
Cell Lines: HEK293T, IMR-90, MRC-5
Cancer Cell?: No
Method: Overexpression
Type of senescence: Unclear
Senescence Effect: Induces
Primary Reference: Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

HGNC symbol: AXL
Aliases: ARK; JTK11; Tyro7; UFO
Common name: AXL receptor tyrosine kinase
Entrez Id: 558
Description: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021].

Gene Ontology

Process:	GO:6468; protein phosphorylation GO:16310; phosphorylation GO:18108; peptidyl-tyrosine phosphorylation GO:30154; cell differentiation GO:2376; immune system process GO:45087; innate immune response GO:6909; phagocytosis GO:7399; nervous system development GO:43066; negative regulation of apoptotic process GO:71222; cellular response to lipopolysaccharide GO:16477; cell migration
	And 39 more GO terms

Cellular component:	GO:16020; membrane GO:16021; integral component of membrane GO:43231; intracellular membrane-bounded organelle GO:5886; plasma membrane GO:5615; extracellular space GO:15629; actin cytoskeleton GO:9986; cell surface GO:5887; integral component of plasma membrane GO:70062; extracellular exosome GO:43235; receptor complex GO:44228; host cell surface
	And 1 more GO terms

Function:	GO:166; nucleotide binding GO:4672; protein kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:5524; ATP binding GO:16301; kinase activity GO:16740; transferase activity GO:4713; protein tyrosine kinase activity GO:4714; transmembrane receptor protein tyrosine kinase activity GO:5515; protein binding GO:1786; phosphatidylserine binding GO:1618; virus receptor activity
	And 3 more GO terms

Show all GO terms