Cell Senescence Entries for BCL2L1

Cell Types
Pancreatic adenocarcinoma, Pancreatic epithelial carcinoma
Cell Lines
MIA PaCa-2, PANC-1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Ikezawa et al. (2019) Increased Bcl-xL Expression in Pancreatic Neoplasia Promotes Carcinogenesis by Inhibiting Senescence and Apoptosis. Cell Mol Gastroenterol Hepatol 4(1)185-200.e1 (PubMed)

BCL2L1 Gene Information

HGNC symbol
BCL2L1 
Aliases
Bcl-X; bcl-xL; bcl-xS; BCL2L; BCLX; PPP1R52 
Common name
BCL2 like 1 
Entrez Id
598
Description
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015].

BCL2L1 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:42981; regulation of apoptotic process
GO:9605; response to external stimulus
GO:43065; positive regulation of apoptotic process
GO:80135; regulation of cellular response to stress
GO:6897; endocytosis
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243; negative regulation of intrinsic apoptotic signaling pathway
GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
And 39 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:31410; cytoplasmic vesicle
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5759; mitochondrial matrix
GO:5741; mitochondrial outer membrane
GO:5856; cytoskeleton
GO:5829; cytosol
And 11 more GO terms
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:19901; protein kinase binding
GO:51434; BH3 domain binding
GO:46982; protein heterodimerization activity
Show all GO terms

Homologs of BCL2L1 in Model Organisms

Danio rerio
bcl2l1
Mus musculus
Bcl2l1
Rattus norvegicus
Bcl2l1

External links

OMIM
600039
Ensembl
ENSG00000171552
Entrez Gene
598
UniGene
732176
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BCL2L1
GeneCards
BCL2L1