Cell Senescence Entries for BCL2L2

Cell Types
Glioblastoma, Lung carcinoma
Cell Lines
H460, U251
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Choi et al. (2019) miR-93-5p suppresses cellular senescence by directly targeting Bcl-w and p21. Biochem Biophys Res Commun 505(4)1134-1140 (PubMed)

BCL2L2 Gene Information

HGNC symbol
BCL2L2 
Aliases
BCL-W; KIAA0271; PPP1R51 
Common name
BCL2 like 2 
Entrez Id
599
Description
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010].

BCL2L2 Ontologies

Gene Ontology
Process: GO:6915; apoptotic process
GO:42981; regulation of apoptotic process
GO:43066; negative regulation of apoptotic process
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
GO:7283; spermatogenesis
GO:2001243; negative regulation of intrinsic apoptotic signaling pathway
GO:2931; response to ischemia
GO:7420; brain development
GO:35795; negative regulation of mitochondrial membrane permeability
GO:60011; Sertoli cell proliferation
And 6 more GO terms
Cellular component: GO:16020; membrane
GO:5739; mitochondrion
GO:31966; mitochondrial membrane
GO:5741; mitochondrial outer membrane
GO:97136; Bcl-2 family protein complex
GO:5737; cytoplasm
GO:5829; cytosol
GO:16021; integral component of membrane
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:97718; disordered domain specific binding
GO:46982; protein heterodimerization activity
GO:44877; protein-containing complex binding
GO:51400; BH domain binding
Show all GO terms

Homologs of BCL2L2 in Model Organisms

Mus musculus
Bcl2l2
Rattus norvegicus
Bcl2l2

External links

OMIM
601931
Ensembl
ENSG00000129473
Entrez Gene
599
UniGene
735863
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BCL2L2
GeneCards
BCL2L2