Cell Senescence Entries for BECN1

Cell Types
Glioblastoma
Cell Lines
U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kaverina et al. (2019) Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX. Oncogene 37(46)6069-6082 (PubMed)

BECN1 Gene Information

HGNC symbol
BECN1 
Aliases
ATG6; VPS30 
Common name
beclin 1 
Entrez Id
8678
Description
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

BECN1 Ontologies

Gene Ontology
Process: GO:6914; autophagy
GO:7049; cell cycle
GO:6915; apoptotic process
GO:51301; cell division
GO:45; autophagosome assembly
GO:6897; endocytosis
GO:32465; regulation of cytokinesis
GO:33554; cellular response to stress
GO:45022; early endosome to late endosome transport
GO:48583; regulation of response to stimulus
GO:51607; defense response to virus
And 48 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5829; cytosol
GO:5768; endosome
GO:5739; mitochondrion
GO:16604; nuclear body
And 13 more GO terms
Function: GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
GO:51020; GTPase binding
GO:19901; protein kinase binding
GO:43548; phosphatidylinositol 3-kinase binding
GO:42802; identical protein binding
Show all GO terms

Homologs of BECN1 in Model Organisms

Danio rerio
becn1
Mus musculus
Becn1
Rattus norvegicus
Becn1

External links

OMIM
604378
Ensembl
ENSG00000126581
Entrez Gene
8678
UniGene
716464
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BECN1
GeneCards
BECN1