Cell Senescence Entries for BMS1

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Inhibits
Primary Reference
Nishimura et al. (2015) Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation. Cell Rep 10(8)1310-23 (PubMed)

BMS1 Gene Information

HGNC symbol
BMS1 
Aliases
BMS1L; KIAA0187 
Common name
BMS1 ribosome biogenesis factor 
Entrez Id
9790
Description
This gene likely encodes a ribosome assembly protein. A similar protein in yeast functions in 35S-rRNA processing, which includes a series of cleavage steps critical for formation of 40S ribosomes. Related pseudogenes exist on chromosomes 2, 9, 10, 15, 16, and 22.[provided by RefSeq, Mar 2009].

BMS1 Ontologies

Gene Ontology
Process: GO:42254; ribosome biogenesis
GO:462; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:479; endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5694; chromosome
GO:30686; 90S preribosome
Function: GO:3723; RNA binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:5525; GTP binding
GO:3924; GTPase activity
GO:34511; U3 snoRNA binding
Hide GO terms

Homologs of BMS1 in Model Organisms

Danio rerio
bms1l
Drosophila melanogaster
CG7728
Mus musculus
Bms1
Rattus norvegicus
Bms1
Saccharomyces cerevisiae
BMS1
Schizosaccharomyces pombe
bms1

External links

OMIM
611448
Ensembl
ENSG00000165733
Entrez Gene
9790
UniGene
10848
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BMS1
GeneCards
BMS1