Cell Senescence Entries for BRIP1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Tu et al. (2012) Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence. Dev Cell 21(6)1077-91 (PubMed)

BRIP1 Gene Information

HGNC symbol
BRIP1 
Aliases
BACH1; FANCJ; OF 
Common name
BRCA1 interacting helicase 1 
Entrez Id
83990
Description
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008].

BRIP1 Ontologies

Gene Ontology
Process: GO:6139; nucleobase-containing compound metabolic process
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:32508; DNA duplex unwinding
GO:6302; double-strand break repair
GO:77; DNA damage checkpoint signaling
GO:6357; regulation of transcription by RNA polymerase II
GO:6289; nucleotide-excision repair
GO:7129; homologous chromosome pairing at meiosis
GO:7283; spermatogenesis
GO:7284; spermatogonial cell division
And 14 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:31965; nuclear membrane
GO:70532; BRCA1-B complex
Function: GO:3677; DNA binding
GO:5524; ATP binding
GO:16818; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:3678; DNA helicase activity
GO:3676; nucleic acid binding
GO:4386; helicase activity
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:16787; hydrolase activity
GO:51536; iron-sulfur cluster binding
GO:5515; protein binding
And 6 more GO terms
Show all GO terms

Homologs of BRIP1 in Model Organisms

Caenorhabditis elegans
dog-1
Danio rerio
brip1
Mus musculus
Brip1

In other databases

LongevityMap
  • This gene is present as BRIP1
CellAge gene expression
  • This gene is present as BRIP1

External links

OMIM
605882
Ensembl
ENSG00000136492
Entrez Gene
83990
UniGene
128903
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BRIP1
GeneCards
BRIP1