Cell Senescence Entries for BTG3
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90, WI-38
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Lin et al. (2012) Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis. Oncogene 31(27)3287-97 (PubMed)
BTG3 Gene Information
- HGNC symbol
- BTG3
- Aliases
- ANA; ANA/BTG3; APRO4; tob55
- Common name
- BTG anti-proliferation factor 3
- Entrez Id
- 10950
- Description
- The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
BTG3 Ontologies
- Gene Ontology
-
Process: GO:8285; negative regulation of cell population proliferation
GO:45930; negative regulation of mitotic cell cycle
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
Show all GO termsFunction: GO:5515; protein binding
Homologs of BTG3 in Model Organisms
In other databases
- LongevityMap
- This gene is present as BTG3
External links
- OMIM
- 605674
- Ensembl
- ENSG00000154640
- Entrez Gene
- 10950
- UniGene
- 473420
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- BTG3
- GeneCards
- BTG3