Cell Senescence Entries for BTG3

Cell Types
Lung fibroblast
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Lin et al. (2012) Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis. Oncogene 31(27)3287-97 (PubMed)

BTG3 Gene Information

HGNC symbol
BTG3 
Aliases
ANA; ANA/BTG3; APRO4; tob55 
Common name
BTG anti-proliferation factor 3 
Entrez Id
10950
Description
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

BTG3 Ontologies

Gene Ontology
Process: GO:8285; negative regulation of cell population proliferation
GO:45930; negative regulation of mitotic cell cycle
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
Function: GO:5515; protein binding
Hide GO terms

Homologs of BTG3 in Model Organisms

Danio rerio
btg3
Mus musculus
Btg3
Rattus norvegicus
Btg3

In other databases

LongevityMap
  • This gene is present as BTG3

External links

OMIM
605674
Ensembl
ENSG00000154640
Entrez Gene
10950
UniGene
473420
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BTG3
GeneCards
BTG3