Cell Senescence Entries for BUB1

Cell Types
Lung fibroblast
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Gjoerup et al. (2007) Surveillance mechanism linking Bub1 loss to the p53 pathway. Proc Natl Acad Sci U S A 104(20)8334-9 (PubMed)

BUB1 Gene Information

HGNC symbol
BUB1 
Aliases
BUB1A; BUB1L; hBUB1 
Common name
BUB1 mitotic checkpoint serine/threonine kinase 
Entrez Id
699
Description
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

BUB1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:51301; cell division
GO:7059; chromosome segregation
GO:51754; meiotic sister chromatid cohesion, centromeric
GO:7094; mitotic spindle assembly checkpoint signaling
GO:7063; regulation of sister chromatid cohesion
GO:51983; regulation of chromosome segregation
GO:8283; cell population proliferation
And 1 more GO terms
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5694; chromosome
GO:775; chromosome, centromeric region
GO:776; kinetochore
GO:43229; intracellular organelle
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
Show all GO terms

Homologs of BUB1 in Model Organisms

Drosophila melanogaster
BubR1
Mus musculus
Bub1
Rattus norvegicus
Bub1
Saccharomyces cerevisiae
BUB1

In other databases

CellAge gene expression
  • This gene is present as BUB1

External links

OMIM
602452
Ensembl
ENSG00000169679
Entrez Gene
699
UniGene
469649
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BUB1
GeneCards
BUB1