Cell Senescence Entries for BUB1B

Cell Types

Colorectal cancer, Melanoma

Cell Lines

A375P, HCT116

Cancer Cell?

Yes

Method

Knockdown

Type of senescence

Oncogene-induced

Senescence Effect

Inhibits

Primary Reference

Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

BUB1B Gene Information

HGNC symbol

BUB1B 

Aliases

Bub1A; BUBR1; MAD3L; SSK1 

Common name

BUB1 mitotic checkpoint serine/threonine kinase B 

Entrez Id

701

Description

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008].

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BUB1B Ontologies

Gene Ontology

Process:

GO:7049; cell cycle GO:16310; phosphorylation GO:6915; apoptotic process GO:6468; protein phosphorylation GO:51301; cell division GO:51754; meiotic sister chromatid cohesion, centromeric GO:7094; mitotic spindle assembly checkpoint signaling GO:51444; negative regulation of ubiquitin-protein transferase activity

Cellular component:	GO:5634; nucleus GO:5737; cytoplasm GO:5829; cytosol GO:5856; cytoskeleton GO:5694; chromosome GO:775; chromosome, centromeric region GO:5815; microtubule organizing center GO:5819; spindle GO:776; kinetochore GO:48471; perinuclear region of cytoplasm GO:33597; mitotic checkpoint complex
	And 4 more GO terms

Function:

GO:166; nucleotide binding GO:4674; protein serine/threonine kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:5524; ATP binding GO:16301; kinase activity GO:16740; transferase activity GO:106310; protein serine kinase activity GO:5515; protein binding GO:4672; protein kinase activity

Show all GO terms

Homologs of BUB1B in Model Organisms

Danio rerio

si:ch1073-192f24.1

Mus musculus

Bub1b

Rattus norvegicus

Bub1b

Schizosaccharomyces pombe

bub1

In other databases

GenAge model organism genes

• A homolog of this gene for Mus musculus is present as Bub1b

GenAge human genes

• This gene is present as BUB1B

CellAge gene expression

• This gene is present as BUB1B

External links

OMIM

602860

Ensembl

ENSG00000156970

Entrez Gene

701

UniGene

513645

1000 Genomes

1000 Genomes

HPRD

GenAtlas

BUB1B

GeneCards

BUB1B