Cell Senescence Entries for CARM1

Cell Types
Human diploid fibroblast
Cell Lines
2BS
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Pang et al. (2013) Loss of CARM1 is linked to reduced HuR function in replicative senescence. BMC Mol Biol 14(2)15 (PubMed)

CARM1 Gene Information

HGNC symbol
CARM1 
Aliases
PRMT4 
Common name
coactivator associated arginine methyltransferase 1 
Entrez Id
10498
Description
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013].

CARM1 Ontologies

Gene Ontology
Process: GO:32259; methylation
GO:6325; chromatin organization
GO:6355; regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:18216; peptidyl-arginine methylation
GO:35246; peptidyl-arginine N-methylation
GO:16571; histone methylation
GO:19919; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:45600; positive regulation of fat cell differentiation
GO:33146; regulation of intracellular estrogen receptor signaling pathway
GO:7568; aging
And 8 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:5515; protein binding
GO:16274; protein-arginine N-methyltransferase activity
GO:3713; transcription coactivator activity
GO:30374; nuclear receptor coactivator activity
GO:976; transcription cis-regulatory region binding
GO:42054; histone methyltransferase activity
GO:35242; protein-arginine omega-N asymmetric methyltransferase activity
GO:70577; lysine-acetylated histone binding
GO:8013; beta-catenin binding
And 4 more GO terms
Show all GO terms

Homologs of CARM1 in Model Organisms

Danio rerio
carm1
Drosophila melanogaster
Art4
Mus musculus
Carm1
Rattus norvegicus
Carm1

External links

OMIM
603934
Ensembl
ENSG00000142453
Entrez Gene
10498
UniGene
323213
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CARM1
GeneCards
CARM1