Cell Senescence Entries for CAV1

Cell Types
Fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Cho et al. (2004) Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem 279(40)42270-8 (PubMed)

CAV1 Gene Information

HGNC symbol
CAV1 
Aliases
CAV 
Common name
caveolin 1 
Entrez Id
857
Description
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010].

CAV1 Ontologies

Gene Ontology
Process: GO:70836; caveola assembly
GO:122; negative regulation of transcription by RNA polymerase II
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:10952; positive regulation of peptidase activity
GO:30154; cell differentiation
GO:72584; caveolin-mediated endocytosis
GO:31623; receptor internalization
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:30335; positive regulation of cell migration
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:97190; apoptotic signaling pathway
And 93 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:5886; plasma membrane
GO:5901; caveola
GO:45121; membrane raft
GO:139; Golgi membrane
GO:31410; cytoplasmic vesicle
GO:32991; protein-containing complex
GO:5768; endosome
GO:5925; focal adhesion
And 15 more GO terms
Function: GO:5515; protein binding
GO:19899; enzyme binding
GO:19901; protein kinase binding
GO:44325; transmembrane transporter binding
GO:60090; molecular adaptor activity
GO:5102; signaling receptor binding
GO:42802; identical protein binding
GO:44877; protein-containing complex binding
GO:51117; ATPase binding
GO:50998; nitric-oxide synthase binding
GO:5113; patched binding
And 7 more GO terms
Show all GO terms

Homologs of CAV1 in Model Organisms

Danio rerio
cav1
Mus musculus
Cav1
Rattus norvegicus
Cav1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Cav1

External links

OMIM
601047
Ensembl
ENSG00000105974
Entrez Gene
857
UniGene
74034
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CAV1
GeneCards
CAV1