Cell Senescence Entries for CBX7
- Cell Types
- Keratinocyte, Lung fibroblast
- Cell Lines
- Primary cell, WI-38
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Gil et al. (2004) Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol 6(1)67-72 (PubMed)
CBX7 Gene Information
- HGNC symbol
- CBX7
- Aliases
- Common name
- chromobox 7
- Entrez Id
- 23492
- Description
- This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016].
CBX7 Ontologies
- Gene Ontology
-
Process: GO:6325; chromatin organization
GO:122; negative regulation of transcription by RNA polymerase II
GO:3006; developmental process involved in reproduction
GO:9410; response to xenobiotic stimulus
GO:32968; positive regulation of transcription elongation from RNA polymerase II promoter
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:31519; PcG protein complex
GO:35102; PRC1 complex
Show all GO termsFunction: GO:5515; protein binding
Homologs of CBX7 in Model Organisms
- Danio rerio
- cbx7a
In other databases
- CellAge gene expression
- This gene is present as CBX7
External links
- OMIM
- 608457
- Ensembl
- ENSG00000100307
- Entrez Gene
- 23492
- UniGene
- 356416
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CBX7
- GeneCards
- CBX7