Cell Senescence Entries for CBX7

Cell Types
Keratinocyte, Lung fibroblast
Cell Lines
Primary cell, WI-38
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Gil et al. (2004) Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol 6(1)67-72 (PubMed)

CBX7 Gene Information

HGNC symbol
CBX7 
Aliases
 
Common name
chromobox 7 
Entrez Id
23492
Description
This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016].

CBX7 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:122; negative regulation of transcription by RNA polymerase II
GO:3006; developmental process involved in reproduction
GO:9410; response to xenobiotic stimulus
GO:32968; positive regulation of transcription elongation from RNA polymerase II promoter
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:31519; PcG protein complex
GO:35102; PRC1 complex
Function: GO:5515; protein binding
Show all GO terms

Homologs of CBX7 in Model Organisms

Danio rerio
cbx7a

In other databases

CellAge gene expression
  • This gene is present as CBX7

External links

OMIM
608457
Ensembl
ENSG00000100307
Entrez Gene
23492
UniGene
356416
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CBX7
GeneCards
CBX7