Cell Senescence Entries for CBX8

Cell Types
Fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Dietrich et al. (2007) Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J 26(6)1637-48 (PubMed)

CBX8 Gene Information

HGNC symbol
CBX8 
Aliases
HPC3; PC3; RC1 
Common name
chromobox 8 
Entrez Id
57332
Description

CBX8 Ontologies

Gene Ontology
Process: GO:50790; regulation of catalytic activity
GO:6325; chromatin organization
GO:122; negative regulation of transcription by RNA polymerase II
GO:16574; histone ubiquitination
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:31519; PcG protein complex
GO:35102; PRC1 complex
GO:151; ubiquitin ligase complex
GO:792; heterochromatin
Function: GO:5515; protein binding
GO:35064; methylated histone binding
GO:3727; single-stranded RNA binding
GO:97027; ubiquitin-protein transferase activator activity
Hide GO terms

Homologs of CBX8 in Model Organisms

Danio rerio
cbx8b
Mus musculus
Cbx8
Rattus norvegicus
Cbx8

External links

OMIM
617354
Ensembl
ENSG00000141570
Entrez Gene
57332
UniGene
387258
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CBX8
GeneCards
CBX8