Cell Senescence Entries for CD82

Cell Types
Melanoma
Cell Lines
A375M, UACC-903
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Khanna et al. (2014) CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas. Oncogene 33(22)2898-908 (PubMed)

CD82 Gene Information

HGNC symbol
CD82 
Aliases
IA4; KAI1; R2; ST6; TSPAN27 
Common name
CD82 molecule 
Entrez Id
3732
Description
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

CD82 Ontologies

Gene Ontology
Process:
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
GO:70062; extracellular exosome
Function: GO:5515; protein binding
Hide GO terms

Homologs of CD82 in Model Organisms

Danio rerio
cd82a
Mus musculus
Cd82
Rattus norvegicus
Cd82

External links

OMIM
600623
Ensembl
ENSG00000085117
Entrez Gene
3732
UniGene
527778
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CD82
GeneCards
CD82