Cell Senescence Entries for CDC6
- Cell Types
- Breast cancer, Nasopharyngeal carcinoma
- Cell Lines
- 6-10B, CNE-2, MCF-7
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Yu et al. (2019) Radiation-promoted CDC6 protein stability contributes to radioresistance by regulating senescence and epithelial to mesenchymal transition. Oncogene 38(4)549-563 (PubMed)
CDC6 Gene Information
- HGNC symbol
- CDC6
- Aliases
- CDC18L
- Common name
- cell division cycle 6
- Entrez Id
- 990
- Description
- The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008].
CDC6 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:51301; cell division
GO:6260; DNA replication
GO:6270; DNA replication initiation
GO:45737; positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:48146; positive regulation of fibroblast proliferation
GO:1904117; cellular response to vasopressin
GO:1904385; cellular response to angiotensin
GO:8285; negative regulation of cell population proliferation
GO:278; mitotic cell cycle
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
And 8 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:45171; intercellular bridge
GO:72686; mitotic spindle
GO:922; spindle pole
GO:51233; spindle midzone
Show all GO termsFunction: GO:5515; protein binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3688; DNA replication origin binding
GO:19900; kinase binding
Homologs of CDC6 in Model Organisms
- Caenorhabditis elegans
- cdc-6
- Danio rerio
- cdc6
- Drosophila melanogaster
- Cdc6
- Mus musculus
- Cdc6
- Rattus norvegicus
- Cdc6
- Saccharomyces cerevisiae
- CDC6
- Schizosaccharomyces pombe
- cdc18
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as CDC6
- CellAge gene expression
- This gene is present as CDC6
External links
- OMIM
- 602627
- Ensembl
- ENSG00000094804
- Entrez Gene
- 990
- UniGene
- 405958
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CDC6
- GeneCards
- CDC6