Cell Senescence Entries for CDC6

Cell Types
Breast cancer, Nasopharyngeal carcinoma
Cell Lines
6-10B, CNE-2, MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Yu et al. (2019) Radiation-promoted CDC6 protein stability contributes to radioresistance by regulating senescence and epithelial to mesenchymal transition. Oncogene 38(4)549-563 (PubMed)

CDC6 Gene Information

HGNC symbol
CDC6 
Aliases
CDC18L 
Common name
cell division cycle 6 
Entrez Id
990
Description
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008].

CDC6 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:51301; cell division
GO:6260; DNA replication
GO:6270; DNA replication initiation
GO:45737; positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:48146; positive regulation of fibroblast proliferation
GO:1904117; cellular response to vasopressin
GO:1904385; cellular response to angiotensin
GO:8285; negative regulation of cell population proliferation
GO:278; mitotic cell cycle
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:33314; mitotic DNA replication checkpoint signaling
GO:76; DNA replication checkpoint signaling
GO:8156; negative regulation of DNA replication
GO:30071; regulation of mitotic metaphase/anaphase transition
GO:7089; traversing start control point of mitotic cell cycle
GO:32467; positive regulation of cytokinesis
GO:51984; positive regulation of chromosome segregation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:45171; intercellular bridge
GO:72686; mitotic spindle
GO:922; spindle pole
GO:51233; spindle midzone
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3688; DNA replication origin binding
GO:19900; kinase binding
Hide GO terms

Homologs of CDC6 in Model Organisms

Caenorhabditis elegans
cdc-6
Danio rerio
cdc6
Drosophila melanogaster
Cdc6
Mus musculus
Cdc6
Rattus norvegicus
Cdc6
Saccharomyces cerevisiae
CDC6
Schizosaccharomyces pombe
cdc18

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as CDC6
CellAge gene expression
  • This gene is present as CDC6

External links

OMIM
602627
Ensembl
ENSG00000094804
Entrez Gene
990
UniGene
405958
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDC6
GeneCards
CDC6