The CDCA4 gene and its putative association with human ageing

Cell Senescence Entries for CDCA4

Cell Types: Mammary fibroblast
Cell Lines: Primary cell
Cancer Cell?: No
Method: Knockdown
Type of senescence: Unclear
Senescence Effect: Inhibits
Primary Reference: Avelar et al. (2021) A multidimensional systems biology analysis of cellular senescence in aging and disease. Genome Biol 21(1)91 (PubMed)

HGNC symbol: CDCA4
Aliases: FLJ20764; Hepp
Common name: cell division cycle associated 4
Entrez Id: 55038
Description: This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014].

Gene Ontology

Process:

GO:51301; cell division

Cellular component:

GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane

Function:

GO:5515; protein binding

Show all GO terms

CellAge gene expression