Cell Senescence Entries for CDCA4

Cell Types
Mammary fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Avelar et al. (2021) A multidimensional systems biology analysis of cellular senescence in aging and disease. Genome Biol 21(1)91 (PubMed)

CDCA4 Gene Information

HGNC symbol
CDCA4 
Aliases
FLJ20764; Hepp 
Common name
cell division cycle associated 4 
Entrez Id
55038
Description
This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014].

CDCA4 Ontologies

Gene Ontology
Process: GO:51301; cell division
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
Function: GO:5515; protein binding
Hide GO terms

Homologs of CDCA4 in Model Organisms

Danio rerio
si:dkey-177p2.7
Mus musculus
Cdca4
Rattus norvegicus
Cdca4

In other databases

CellAge gene expression
  • This gene is present as CDCA4

External links

OMIM
612270
Ensembl
ENSG00000170779
Entrez Gene
55038
UniGene
34045
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDCA4
GeneCards
CDCA4