Cell Senescence Entries for CDH1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Gao et al. (2009) Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell 20(14)3305-16 (PubMed)

CDH1 Gene Information

HGNC symbol
CDH1 
Aliases
CD324; UVO; uvomorulin 
Common name
cadherin 1 
Entrez Id
999
Description
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015].

CDH1 Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:7156; homophilic cell adhesion via plasma membrane adhesion molecules
GO:10468; regulation of gene expression
GO:98609; cell-cell adhesion
GO:34332; adherens junction organization
GO:7416; synapse assembly
GO:9410; response to xenobiotic stimulus
GO:9636; response to toxic substance
GO:10033; response to organic substance
GO:21983; pituitary gland development
GO:31175; neuron projection development
GO:99576; regulation of protein catabolic process at postsynapse, modulating synaptic transmission
GO:45893; positive regulation of transcription, DNA-templated
GO:30336; negative regulation of cell migration
GO:22408; negative regulation of cell-cell adhesion
GO:72659; protein localization to plasma membrane
GO:42307; positive regulation of protein import into nucleus
GO:71285; cellular response to lithium ion
GO:71681; cellular response to indole-3-methanol
GO:98742; cell-cell adhesion via plasma-membrane adhesion molecules
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:5886; plasma membrane
GO:5768; endosome
GO:16600; flotillin complex
GO:5912; adherens junction
GO:30054; cell junction
GO:30027; lamellipodium
GO:5737; cytoplasm
GO:5576; extracellular region
GO:98794; postsynapse
GO:98978; glutamatergic synapse
GO:70062; extracellular exosome
GO:43296; apical junction complex
GO:16342; catenin complex
GO:15629; actin cytoskeleton
GO:48471; perinuclear region of cytoplasm
GO:9898; cytoplasmic side of plasma membrane
GO:30864; cortical actin cytoskeleton
GO:16328; lateral plasma membrane
GO:5802; trans-Golgi network
GO:110165; cellular anatomical entity
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:5509; calcium ion binding
GO:42802; identical protein binding
GO:45296; cadherin binding
GO:8013; beta-catenin binding
GO:30506; ankyrin binding
GO:50839; cell adhesion molecule binding
GO:32794; GTPase activating protein binding
GO:45295; gamma-catenin binding
Hide GO terms

Homologs of CDH1 in Model Organisms

Mus musculus
Cdh1
Rattus norvegicus
Cdh1

External links

OMIM
192090
Ensembl
ENSG00000039068
Entrez Gene
999
UniGene
461086
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDH1
GeneCards
CDH1