Cell Senescence Entries for CDK2AP1

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Alsayegh et al. (2016) Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence. PLoS One 10(3)e0120782 (PubMed)

CDK2AP1 Gene Information

HGNC symbol
CDK2AP1 
Aliases
doc-1; DOC1; DORC1; p12DOC-1; ST19 
Common name
cyclin dependent kinase 2 associated protein 1 
Entrez Id
8099
Description
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].

CDK2AP1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:1934; positive regulation of protein phosphorylation
GO:6261; DNA-dependent DNA replication
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:48471; perinuclear region of cytoplasm
GO:5737; cytoplasm
Function: GO:5515; protein binding
GO:70182; DNA polymerase binding
Hide GO terms

Homologs of CDK2AP1 in Model Organisms

Mus musculus
Cdk2ap1
Rattus norvegicus
Cdk2ap1

External links

OMIM
602198
Ensembl
ENSG00000111328
Entrez Gene
8099
UniGene
433201
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDK2AP1
GeneCards
CDK2AP1