Cell Senescence Entries for CDKN1A

Cell Types
Fibroblast
Cell Lines
LF1
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced, Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Brown et al. (1997) Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277(5327)831-4 (PubMed)

CDKN1A Gene Information

HGNC symbol
CDKN1A 
Aliases
CAP20; CDKN1; CIP1; P21; p21CIP1; p21Cip1/Waf1; SDI1; WAF1 
Common name
cyclin dependent kinase inhibitor 1A 
Entrez Id
1026
Description
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015].

CDKN1A Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:16310; phosphorylation
GO:51726; regulation of cell cycle
GO:7346; regulation of mitotic cell cycle
GO:60255; regulation of macromolecule metabolic process
GO:72331; signal transduction by p53 class mediator
GO:7095; mitotic G2 DNA damage checkpoint signaling
GO:7507; heart development
GO:32091; negative regulation of protein binding
GO:90398; cellular senescence
GO:8285; negative regulation of cell population proliferation
And 39 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:16604; nuclear body
GO:5829; cytosol
GO:32991; protein-containing complex
GO:5730; nucleolus
GO:307; cyclin-dependent protein kinase holoenzyme complex
GO:70557; PCNA-p21 complex
Function: GO:46872; metal ion binding
GO:16301; kinase activity
GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
GO:4860; protein kinase inhibitor activity
GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:19901; protein kinase binding
GO:44877; protein-containing complex binding
GO:19912; cyclin-dependent protein kinase activating kinase activity
GO:30332; cyclin binding
GO:140311; protein sequestering activity
And 1 more GO terms
Show all GO terms

Homologs of CDKN1A in Model Organisms

Danio rerio
cdkn1a
Mus musculus
Cdkn1a
Rattus norvegicus
Cdkn1a

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Cdkn1a
GenAge human genes
  • This gene is present as CDKN1A
LongevityMap
  • This gene is present as CDKN1A
CellAge gene expression
  • This gene is present as CDKN1A

External links

OMIM
116899
Ensembl
ENSG00000124762
Entrez Gene
1026
UniGene
732576
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDKN1A
GeneCards
CDKN1A