Cell Senescence Entries for CDKN1C

Cell Types
Liver cancer
Cell Lines
Hep G2, SNU-398
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Giovannini et al. (2012) CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma. Am J Pathol 181(2)413-22 (PubMed)

CDKN1C Gene Information

HGNC symbol
CDKN1C 
Aliases
BWCR; BWS; KIP2; P57 
Common name
cyclin dependent kinase inhibitor 1C 
Entrez Id
1028
Description
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

CDKN1C Ontologies

Gene Ontology
Process: GO:43086; negative regulation of catalytic activity
GO:51726; regulation of cell cycle
GO:7346; regulation of mitotic cell cycle
GO:60255; regulation of macromolecule metabolic process
GO:45736; negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:7049; cell cycle
GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:30511; positive regulation of transforming growth factor beta receptor signaling pathway
GO:45930; negative regulation of mitotic cell cycle
GO:42326; negative regulation of phosphorylation
And 20 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
Function: GO:4860; protein kinase inhibitor activity
GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:5515; protein binding
GO:44877; protein-containing complex binding
Show all GO terms

Homologs of CDKN1C in Model Organisms

Mus musculus
Cdkn1c
Rattus norvegicus
Cdkn1c

External links

OMIM
600856
Ensembl
ENSG00000129757
Entrez Gene
1028
UniGene
106070
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CDKN1C
GeneCards
CDKN1C