Cell Senescence Entries for CEBPG

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Huggins et al. (2013) C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ. Mol Cell Biol 33(16)3242-58 (PubMed)

CEBPG Gene Information

HGNC symbol
CEBPG 
Aliases
GPE1BP; IG/EBP-1 
Common name
CCAAT enhancer binding protein gamma 
Entrez Id
1054
Description
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011].

CEBPG Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6955; immune response
GO:45739; positive regulation of DNA repair
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:32729; positive regulation of interferon-gamma production
GO:43433; negative regulation of DNA-binding transcription factor activity
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:1889; liver development
GO:43388; positive regulation of DNA binding
GO:30183; B cell differentiation
GO:42267; natural killer cell mediated cytotoxicity
GO:16071; mRNA metabolic process
GO:43353; enucleate erythrocyte differentiation
GO:140467; integrated stress response signaling
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:42802; identical protein binding
Hide GO terms

Homologs of CEBPG in Model Organisms

Caenorhabditis elegans
cebp-2
Danio rerio
cebpg
Drosophila melanogaster
CG6272
Mus musculus
Cebpg
Rattus norvegicus
Cebpg

External links

OMIM
138972
Ensembl
ENSG00000153879
Entrez Gene
1054
UniGene
429666
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CEBPG
GeneCards
CEBPG