Cell Senescence Entries for CENPA

Cell Types
Lung fibroblast
Cell Lines
TIG-3
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Maehara et al. (2010) CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses. Mol Cell Biol 30(9)2090-104 (PubMed)

CENPA Gene Information

HGNC symbol
CENPA 
Aliases
CenH3; CENP-A 
Common name
centromere protein A 
Entrez Id
1058
Description
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015].

CENPA Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:51301; cell division
GO:132; establishment of mitotic spindle orientation
GO:281; mitotic cytokinesis
GO:71459; protein localization to chromosome, centromeric region
GO:51382; kinetochore assembly
GO:61644; protein localization to CENP-A containing chromatin
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:786; nucleosome
GO:5694; chromosome
GO:775; chromosome, centromeric region
GO:776; kinetochore
GO:5829; cytosol
GO:43505; CENP-A containing nucleosome
GO:779; condensed chromosome, centromeric region
GO:939; inner kinetochore
GO:5721; pericentric heterochromatin
And 1 more GO terms
Function: GO:3677; DNA binding
GO:46982; protein heterodimerization activity
GO:5515; protein binding
GO:3682; chromatin binding
Show all GO terms

Homologs of CENPA in Model Organisms

Mus musculus
Cenpa
Rattus norvegicus
Cenpa

In other databases

CellAge gene expression
  • This gene is present as CENPA

External links

OMIM
117139
Ensembl
ENSG00000115163
Entrez Gene
1058
UniGene
1594
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CENPA
GeneCards
CENPA