Cell Senescence Entries for CHD5

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Induces
Primary Reference
Mallette et al. (2013) JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5. Cell Rep 2(5)1233-43 (PubMed)

CHD5 Gene Information

HGNC symbol
CHD5 
Aliases
 
Common name
chromodomain helicase DNA binding protein 5 
Entrez Id
26038
Description
This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012].

CHD5 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:30154; cell differentiation
GO:32508; DNA duplex unwinding
GO:6338; chromatin remodeling
GO:7399; nervous system development
GO:7283; spermatogenesis
GO:6357; regulation of transcription by RNA polymerase II
GO:8285; negative regulation of cell population proliferation
GO:43967; histone H4 acetylation
GO:35093; spermatogenesis, exchange of chromosomal proteins
GO:21895; cerebral cortex neuron differentiation
And 3 more GO terms
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:16020; membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:792; heterochromatin
GO:16581; NuRD complex
GO:43233; organelle lumen
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:3678; DNA helicase activity
GO:140658; ATP-dependent chromatin remodeler activity
GO:61628; H3K27me3 modified histone binding
Show all GO terms

Homologs of CHD5 in Model Organisms

Caenorhabditis elegans
chd-3
Mus musculus
Chd5
Rattus norvegicus
Chd5

External links

OMIM
610771
Ensembl
ENSG00000116254
Entrez Gene
26038
UniGene
522898
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CHD5
GeneCards
CHD5