The CHEK2 gene and its putative association with human ageing

Cell Senescence Entries for CHEK2

Cell Types: Cervical cancer, Colon cancer
Cell Lines: DLD1, HeLa
Cancer Cell?: Yes
Method: Overexpression
Type of senescence: Unclear
Senescence Effect: Induces
Primary Reference: Chen et al. (2005) Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: checkpoint activation as a strategy against cancer. Cancer Res 65(14)6017-21 (PubMed)

HGNC symbol: CHEK2
Aliases: bA444G7; CDS1; CHK2; HuCds1; PP1425; RAD53
Common name: checkpoint kinase 2
Entrez Id: 11200
Description: In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].

Gene Ontology

Process:	GO:6468; protein phosphorylation GO:7049; cell cycle GO:16310; phosphorylation GO:6915; apoptotic process GO:6355; regulation of transcription, DNA-templated GO:51301; cell division GO:6281; DNA repair GO:6974; cellular response to DNA damage stimulus GO:45893; positive regulation of transcription, DNA-templated GO:6302; double-strand break repair GO:42176; regulation of protein catabolic process
	And 26 more GO terms

Cellular component:

GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:16605; PML body
GO:5737; cytoplasm

Function:	GO:4672; protein kinase activity GO:5524; ATP binding GO:5515; protein binding GO:46872; metal ion binding GO:166; nucleotide binding GO:4674; protein serine/threonine kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:16301; kinase activity GO:16740; transferase activity GO:106310; protein serine kinase activity GO:31625; ubiquitin protein ligase binding
	And 4 more GO terms

Show all GO terms

GenAge model organism genes

GenAge human genes