Cell Senescence Entries for CKB

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

CKB Gene Information

HGNC symbol
CKB 
Aliases
CKBB 
Common name
creatine kinase B 
Entrez Id
1152
Description
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008].

CKB Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:19752; carboxylic acid metabolic process
GO:46314; phosphocreatine biosynthetic process
GO:21762; substantia nigra development
GO:7420; brain development
GO:21549; cerebellum development
GO:30644; cellular chloride ion homeostasis
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:5615; extracellular space
GO:70062; extracellular exosome
GO:5634; nucleus
GO:30425; dendrite
GO:43025; neuronal cell body
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:3824; catalytic activity
GO:16772; transferase activity, transferring phosphorus-containing groups
GO:4111; creatine kinase activity
GO:5515; protein binding
GO:31625; ubiquitin protein ligase binding
Show all GO terms

Homologs of CKB in Model Organisms

Danio rerio
ckba
Mus musculus
Ckb
Rattus norvegicus
Ckb

External links

OMIM
123280
Ensembl
ENSG00000166165
Entrez Gene
1152
UniGene
173724
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CKB
GeneCards
CKB