Cell Senescence Entries for CLCA2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Tanikawa et al. (2012) CLCA2 as a p53-inducible senescence mediator. Neoplasia 14(2)141-9 (PubMed)

CLCA2 Gene Information

HGNC symbol
CLCA2 
Aliases
CLCRG2 
Common name
chloride channel accessory 2 
Entrez Id
9635
Description
This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016].

CLCA2 Ontologies

Gene Ontology
Process: GO:6811; ion transport
GO:6508; proteolysis
GO:7155; cell adhesion
GO:6821; chloride transport
GO:34220; ion transmembrane transport
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5576; extracellular region
GO:31965; nuclear membrane
GO:30054; cell junction
GO:5887; integral component of plasma membrane
GO:9925; basal plasma membrane
Function: GO:46872; metal ion binding
GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:8237; metallopeptidase activity
GO:5229; intracellular calcium activated chloride channel activity
GO:4222; metalloendopeptidase activity
GO:5254; chloride channel activity
GO:15276; ligand-gated ion channel activity
Show all GO terms

Homologs of CLCA2 in Model Organisms

Danio rerio
uncharacterized_F1QR
Mus musculus
Clca2
Rattus norvegicus
Clca2

External links

OMIM
604003
Ensembl
ENSG00000137975
Entrez Gene
9635
UniGene
241551
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CLCA2
GeneCards
CLCA2