Cell Senescence Entries for CLSPN

Cell Types
Cervical cancer, Foreskin fibroblast
Cell Lines
BJ1-hTERT, U2OS
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Bianco et al. (2019) Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner. Nat Commun 10(1)910 (PubMed)

CLSPN Gene Information

HGNC symbol
CLSPN 
Aliases
 
Common name
claspin 
Entrez Id
63967
Description
The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

CLSPN Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:18105; peptidyl-serine phosphorylation
GO:7095; mitotic G2 DNA damage checkpoint signaling
GO:77; DNA damage checkpoint signaling
GO:33314; mitotic DNA replication checkpoint signaling
GO:32147; activation of protein kinase activity
GO:76; DNA replication checkpoint signaling
Cellular component: GO:5634; nucleus
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:10997; anaphase-promoting complex binding
GO:217; DNA secondary structure binding
Show all GO terms

Homologs of CLSPN in Model Organisms

Drosophila melanogaster
CG32251
Mus musculus
Clspn
Rattus norvegicus
Clspn

In other databases

CellAge gene expression
  • This gene is present as CLSPN

External links

OMIM
605434
Ensembl
ENSG00000092853
Entrez Gene
63967
UniGene
175613
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CLSPN
GeneCards
CLSPN