Cell Senescence Entries for CPEB1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
Primary cell, WI-38
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Burns et al. (2009) CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation. Genes Dev 22(24)3449-60 (PubMed)

CPEB1 Gene Information

HGNC symbol
CPEB1 
Aliases
CPEB; FLJ13203 
Common name
cytoplasmic polyadenylation element binding protein 1 
Entrez Id
64506
Description
This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

CPEB1 Ontologies

Gene Ontology
Process: GO:6412; translation
GO:6397; mRNA processing
GO:6417; regulation of translation
GO:2000766; negative regulation of cytoplasmic translation
GO:71230; cellular response to amino acid stimulus
GO:32869; cellular response to insulin stimulus
GO:71456; cellular response to hypoxia
GO:1900365; positive regulation of mRNA polyadenylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:30054; cell junction
GO:42995; cell projection
GO:30425; dendrite
GO:45202; synapse
GO:932; P-body
GO:14069; postsynaptic density
And 3 more GO terms
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:46872; metal ion binding
GO:3730; mRNA 3'-UTR binding
GO:45182; translation regulator activity
GO:35925; mRNA 3'-UTR AU-rich region binding
GO:5515; protein binding
GO:900; translation repressor activity, mRNA regulatory element binding
GO:8135; translation factor activity, RNA binding
GO:43022; ribosome binding
Show all GO terms

Homologs of CPEB1 in Model Organisms

Danio rerio
cpeb1
Mus musculus
Cpeb1
Rattus norvegicus
Cpeb1

External links

OMIM
607342
Ensembl
ENSG00000214575
Entrez Gene
64506
UniGene
547988
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CPEB1
GeneCards
CPEB1