Cell Senescence Entries for CTSB

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Xiao et al. (2019) Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. Genome Res 28(11)1601-1610 (PubMed)

CTSB Gene Information

HGNC symbol
CTSB 
Aliases
APPS; CPSB; RECEUP 
Common name
cathepsin B 
Entrez Id
1508
Description
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Sep 2020].

CTSB Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:50790; regulation of catalytic activity
GO:42981; regulation of apoptotic process
GO:30855; epithelial cell differentiation
GO:51603; proteolysis involved in cellular protein catabolic process
GO:10466; negative regulation of peptidase activity
GO:30574; collagen catabolic process
GO:97067; cellular response to thyroid hormone stimulus
GO:6590; thyroid hormone generation
GO:46697; decidualization
GO:46718; viral entry into host cell
And 1 more GO terms
Cellular component: GO:5615; extracellular space
GO:16020; membrane
GO:5886; plasma membrane
GO:5576; extracellular region
GO:16324; apical plasma membrane
GO:5764; lysosome
GO:48471; perinuclear region of cytoplasm
GO:42470; melanosome
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:1904813; ficolin-1-rich granule lumen
And 4 more GO terms
Function: GO:5515; protein binding
GO:8233; peptidase activity
GO:8234; cysteine-type peptidase activity
GO:16787; hydrolase activity
GO:4197; cysteine-type endopeptidase activity
GO:5518; collagen binding
GO:43394; proteoglycan binding
GO:4175; endopeptidase activity
Show all GO terms

Homologs of CTSB in Model Organisms

Caenorhabditis elegans
cpr-5
Danio rerio
ctsba
Drosophila melanogaster
CtsB1
Mus musculus
Ctsb
Rattus norvegicus
Ctsb

In other databases

CellAge gene expression
  • This gene is present as CTSB

External links

OMIM
116810
Ensembl
ENSG00000164733
Entrez Gene
1508
UniGene
520898
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CTSB
GeneCards
CTSB