Cell Senescence Entries for CTSD

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Su et al. (2018) Lowering Endogenous Cathepsin D Abundance Results in Reactive Oxygen Species Accumulation and Cell Senescence. Mol Cell Proteomics 16(7)1217-1232 (PubMed)

CTSD Gene Information

HGNC symbol
CTSD 
Aliases
CLN10; CPSD 
Common name
cathepsin D 
Entrez Id
1509
Description
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015].

CTSD Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:19538; protein metabolic process
GO:19886; antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:43280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:42159; lipoprotein catabolic process
GO:43065; positive regulation of apoptotic process
GO:70201; regulation of establishment of protein localization
Cellular component: GO:5615; extracellular space
GO:5764; lysosome
GO:5576; extracellular region
GO:45121; membrane raft
GO:42470; melanosome
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:1904813; ficolin-1-rich granule lumen
GO:35580; specific granule lumen
GO:1904724; tertiary granule lumen
GO:43202; lysosomal lumen
And 3 more GO terms
Function: GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:4190; aspartic-type endopeptidase activity
GO:5515; protein binding
GO:4197; cysteine-type endopeptidase activity
GO:70001; aspartic-type peptidase activity
Show all GO terms

Homologs of CTSD in Model Organisms

Danio rerio
ctsd
Mus musculus
Ctsd
Rattus norvegicus
Ctsd

In other databases

CellAge gene expression
  • This gene is present as CTSD

External links

OMIM
116840
Ensembl
ENSG00000117984
Entrez Gene
1509
UniGene
654447
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CTSD
GeneCards
CTSD