Cell Senescence Entries for DDB2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Roy et al. (2010) DDB2, an essential mediator of premature senescence. Mol Cell Biol 30(11)2681-92 (PubMed)

DDB2 Gene Information

HGNC symbol
DDB2 
Aliases
DDBB; FLJ34321; UV-DDB2; XPE 
Common name
damage specific DNA binding protein 2 
Entrez Id
1643
Description
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].

DDB2 Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:16567; protein ubiquitination
GO:6974; cellular response to DNA damage stimulus
GO:51865; protein autoubiquitination
GO:209; protein polyubiquitination
GO:9411; response to UV
GO:35518; histone H2A monoubiquitination
GO:6289; nucleotide-excision repair
GO:70914; UV-damage excision repair
GO:6290; pyrimidine dimer repair
GO:34644; cellular response to UV
And 1 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:30054; cell junction
GO:80008; Cul4-RING E3 ubiquitin ligase complex
GO:32991; protein-containing complex
GO:31465; Cul4B-RING E3 ubiquitin ligase complex
GO:31464; Cul4A-RING E3 ubiquitin ligase complex
Function: GO:3684; damaged DNA binding
GO:5515; protein binding
GO:3677; DNA binding
GO:4842; ubiquitin-protein transferase activity
GO:44877; protein-containing complex binding
Show all GO terms

Homologs of DDB2 in Model Organisms

Danio rerio
ddb2
Mus musculus
Ddb2
Rattus norvegicus
Ddb2

In other databases

LongevityMap
  • This gene is present as DDB2
CellAge gene expression
  • This gene is present as DDB2

External links

OMIM
600811
Ensembl
ENSG00000134574
Entrez Gene
1643
UniGene
700338
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DDB2
GeneCards
DDB2