Cell Senescence Entries for DGCR8

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Gómez-Cabello et al. (2014) DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts. Aging Cell 12(5)923-31 (PubMed)

DGCR8 Gene Information

HGNC symbol
DGCR8 
Aliases
C22orf12; DGCRK6; Gy1; pasha 
Common name
DGCR8 microprocessor complex subunit 
Entrez Id
54487
Description
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].

DGCR8 Ontologies

Gene Ontology
Process: GO:31053; primary miRNA processing
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:16604; nuclear body
GO:5730; nucleolus
GO:5737; cytoplasm
GO:70877; microprocessor complex
Function: GO:3723; RNA binding
GO:46872; metal ion binding
GO:5515; protein binding
GO:20037; heme binding
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:3725; double-stranded RNA binding
GO:70878; primary miRNA binding
GO:140517; protein-RNA adaptor activity
Hide GO terms

Homologs of DGCR8 in Model Organisms

Caenorhabditis elegans
pash-1
Danio rerio
dgcr8
Drosophila melanogaster
pasha
Mus musculus
Dgcr8
Rattus norvegicus
Dgcr8

External links

OMIM
609030
Ensembl
ENSG00000128191
Entrez Gene
54487
UniGene
713579
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DGCR8
GeneCards
DGCR8