Cell Senescence Entries for DHCR24

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Mutation
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wu et al. (2005) Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. Nature 432(7017)640-5 (PubMed)

DHCR24 Gene Information

HGNC symbol
DHCR24 
Aliases
DCE; KIAA0018; seladin-1 
Common name
24-dehydrocholesterol reductase 
Entrez Id
1718
Description
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008].

DHCR24 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:6629; lipid metabolic process
GO:6694; steroid biosynthetic process
GO:6695; cholesterol biosynthetic process
GO:8202; steroid metabolic process
GO:8203; cholesterol metabolic process
GO:16126; sterol biosynthetic process
GO:51726; regulation of cell cycle
GO:6979; response to oxidative stress
GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
And 15 more GO terms
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:139; Golgi membrane
GO:5737; cytoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
Function: GO:16491; oxidoreductase activity
GO:50660; flavin adenine dinucleotide binding
GO:71949; FAD binding
GO:19899; enzyme binding
GO:5515; protein binding
GO:50614; delta24-sterol reductase activity
GO:42605; peptide antigen binding
GO:246; delta24(24-1) sterol reductase activity
GO:16628; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Show all GO terms

Homologs of DHCR24 in Model Organisms

Caenorhabditis elegans
F52H2.6
Danio rerio
dhcr24
Mus musculus
Dhcr24
Rattus norvegicus
Dhcr24

External links

OMIM
606418
Ensembl
ENSG00000116133
Entrez Gene
1718
UniGene
498727
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DHCR24
GeneCards
DHCR24