Cell Senescence Entries for DICER1

Cell Types
Lung fibroblast
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Noren Hooten et al. (2017) Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence. Aging Cell 15(3)572-81 (PubMed)

DICER1 Gene Information

HGNC symbol
DICER1 
Aliases
Dicer; HERNA; K12H4.8-LIKE; KIAA0928; MNG1 
Common name
dicer 1, ribonuclease III 
Entrez Id
23405
Description
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021].

DICER1 Ontologies

Gene Ontology
Process: GO:6396; RNA processing
GO:30422; production of siRNA involved in RNA interference
GO:31054; pre-miRNA processing
GO:10629; negative regulation of gene expression
GO:31047; gene silencing by RNA
GO:6309; apoptotic DNA fragmentation
GO:122; negative regulation of transcription by RNA polymerase II
GO:21675; nerve development
GO:35196; production of miRNAs involved in gene silencing by miRNA
GO:35280; miRNA loading onto RISC involved in gene silencing by miRNA
GO:16078; tRNA catabolic process
GO:32720; negative regulation of tumor necrosis factor production
GO:90501; RNA phosphodiester bond hydrolysis
GO:48812; neuron projection morphogenesis
GO:30423; targeting of mRNA for destruction involved in RNA interference
GO:10586; miRNA metabolic process
GO:35087; siRNA loading onto RISC involved in RNA interference
GO:10626; negative regulation of Schwann cell proliferation
GO:14040; positive regulation of Schwann cell differentiation
GO:31643; positive regulation of myelination
GO:32290; peripheral nervous system myelin formation
GO:36404; conversion of ds siRNA to ss siRNA
GO:38061; NIK/NF-kappaB signaling
GO:90502; RNA phosphodiester bond hydrolysis, endonucleolytic
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:35194; post-transcriptional gene silencing by RNA
GO:70918; production of small RNA involved in gene silencing by RNA
Cellular component: GO:5737; cytoplasm
GO:48471; perinuclear region of cytoplasm
GO:5634; nucleus
GO:16442; RISC complex
GO:5829; cytosol
GO:70578; RISC-loading complex
GO:70062; extracellular exosome
GO:33167; ARC complex
Function: GO:3677; DNA binding
GO:5524; ATP binding
GO:5515; protein binding
GO:3723; RNA binding
GO:16787; hydrolase activity
GO:4525; ribonuclease III activity
GO:16891; endoribonuclease activity, producing 5'-phosphomonoesters
GO:166; nucleotide binding
GO:46872; metal ion binding
GO:4518; nuclease activity
GO:4386; helicase activity
GO:4519; endonuclease activity
GO:19904; protein domain specific binding
GO:3725; double-stranded RNA binding
GO:70883; pre-miRNA binding
GO:4530; deoxyribonuclease I activity
GO:35197; siRNA binding
GO:4521; endoribonuclease activity
Hide GO terms

Homologs of DICER1 in Model Organisms

Caenorhabditis elegans
dcr-1
Danio rerio
dicer1
Drosophila melanogaster
Dcr-1
Mus musculus
Dicer1
Rattus norvegicus
Dicer1
Schizosaccharomyces pombe
dcr1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as dcr-1

External links

OMIM
606241
Ensembl
ENSG00000100697
Entrez Gene
23405
UniGene
738957
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DICER1
GeneCards
DICER1