The DIDO1 gene and its putative association with human ageing

Cell Senescence Entries for DIDO1

Cell Types: Fetal lung fibroblast, Umbilical cord fibroblast
Cell Lines: HUC-F2, TIG-1
Cancer Cell?: No
Method: Knockdown
Type of senescence: Unclear
Senescence Effect: Inhibits
Primary Reference: Udono et al. (2016) Impaired ATP6V0A2 expression contributes to Golgi dispersion and glycosylation changes in senescent cells. Sci Rep 5(2)17342 (PubMed)

HGNC symbol: DIDO1
Aliases: BYE1; C20orf158; DATF1; DIO-1; DIO1; dJ885L7.8; FLJ11265; KIAA0333
Common name: death inducer-obliterator 1
Entrez Id: 11083
Description: Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008].

Gene Ontology

Process:

GO:6915; apoptotic process
GO:6351; transcription, DNA-templated
GO:97190; apoptotic signaling pathway

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5819; spindle

Function:

GO:3723; RNA binding
GO:46872; metal ion binding

Show all GO terms