Cell Senescence Entries for DKC1

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Inhibits
Primary Reference
Nishimura et al. (2015) Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation. Cell Rep 10(8)1310-23 (PubMed)

DKC1 Gene Information

HGNC symbol
DKC1 
Aliases
Cbf5; DKC; dyskerin; NAP57; NOLA4; XAP101 
Common name
dyskerin pseudouridine synthase 1 
Entrez Id
1736
Description
This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

DKC1 Ontologies

Gene Ontology
Process: GO:6396; RNA processing
GO:1522; pseudouridine synthesis
GO:9451; RNA modification
GO:7004; telomere maintenance via telomerase
GO:6364; rRNA processing
GO:42254; ribosome biogenesis
GO:51973; positive regulation of telomerase activity
GO:455; enzyme-directed rRNA pseudouridine synthesis
GO:495; box H/ACA RNA 3'-end processing
GO:31118; rRNA pseudouridine synthesis
GO:31120; snRNA pseudouridine synthesis
And 10 more GO terms
Cellular component: GO:5654; nucleoplasm
GO:1650; fibrillar center
GO:5697; telomerase holoenzyme complex
GO:90661; box H/ACA telomerase RNP complex
GO:5634; nucleus
GO:5737; cytoplasm
GO:5730; nucleolus
GO:15030; Cajal body
GO:31429; box H/ACA snoRNP complex
GO:72589; box H/ACA scaRNP complex
Function: GO:3723; RNA binding
GO:9982; pseudouridine synthase activity
GO:16853; isomerase activity
GO:5515; protein binding
GO:3720; telomerase activity
GO:70034; telomerase RNA binding
GO:34513; box H/ACA snoRNA binding
Show all GO terms

Homologs of DKC1 in Model Organisms

Caenorhabditis elegans
K01G5.5
Danio rerio
dkc1
Drosophila melanogaster
Nop60B
Mus musculus
Dkc1
Rattus norvegicus
Dkc1
Saccharomyces cerevisiae
CBF5
Schizosaccharomyces pombe
cbf5

In other databases

CellAge gene expression
  • This gene is present as DKC1

External links

OMIM
300126
Ensembl
ENSG00000130826
Entrez Gene
1736
UniGene
4747
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DKC1
GeneCards
DKC1