Cell Senescence Entries for DOT1L

Cell Types
Lung cancer, Lung fibroblast
Cell Lines
A549, IMR-90, NCI-H1299
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2012) Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation. J Biol Chem 287(8)5588-99 (PubMed)

DOT1L Gene Information

HGNC symbol
DOT1L 
Aliases
DOT1; KIAA1814; KMT4 
Common name
DOT1 like histone lysine methyltransferase 
Entrez Id
84444
Description
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011].

DOT1L Ontologies

Gene Ontology
Process: GO:51726; regulation of cell cycle
GO:31507; heterochromatin assembly
GO:34729; histone H3-K79 methylation
GO:32259; methylation
GO:6325; chromatin organization
GO:45893; positive regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:77; DNA damage checkpoint signaling
GO:6281; DNA repair
GO:8284; positive regulation of cell population proliferation
GO:2000677; regulation of transcription regulatory region DNA binding
GO:46425; regulation of receptor signaling pathway via JAK-STAT
GO:32200; telomere organization
GO:10467; gene expression
Cellular component: GO:5634; nucleus
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:32991; protein-containing complex
GO:5737; cytoplasm
Function: GO:18024; histone-lysine N-methyltransferase activity
GO:31151; histone methyltransferase activity (H3-K79 specific)
GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:3677; DNA binding
GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:42054; histone methyltransferase activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
Hide GO terms

Homologs of DOT1L in Model Organisms

Caenorhabditis elegans
CELE_Y39G10AR.18
Danio rerio
dot1l
Drosophila melanogaster
gpp
Mus musculus
Dot1l
Rattus norvegicus
Dot1l

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as dot-1.1

External links

OMIM
607375
Ensembl
ENSG00000104885
Entrez Gene
84444
UniGene
713641
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DOT1L
GeneCards
DOT1L