Cell Senescence Entries for DPY30

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Simboeck et al. (2013) DPY30 regulates pathways in cellular senescence through ID protein expression. EMBO J 32(16)2217-30 (PubMed)

DPY30 Gene Information

HGNC symbol
DPY30 
Aliases
Cps25; HDPY-30; Saf19 
Common name
dpy-30 histone methyltransferase complex regulatory subunit 
Entrez Id
84661
Description
This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016].

DPY30 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:16197; endosomal transport
GO:51568; histone H3-K4 methylation
Cellular component: GO:5634; nucleus
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5802; trans-Golgi network
GO:48188; Set1C/COMPASS complex
GO:44666; MLL3/4 complex
GO:44665; MLL1/2 complex
GO:71339; MLL1 complex
GO:35097; histone methyltransferase complex
Function: GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:42802; identical protein binding
Hide GO terms

Homologs of DPY30 in Model Organisms

Danio rerio
dpy30
Drosophila melanogaster
Dpy-30L2
Mus musculus
Dpy30
Rattus norvegicus
Dpy30

External links

OMIM
612032
Ensembl
ENSG00000162961
Entrez Gene
84661
UniGene
679657
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DPY30
GeneCards
DPY30