Cell Senescence Entries for DYRK1A

Cell Types
Glioblastoma, Osteosarcoma
Cell Lines
T98G, U2OS
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Litovchick et al. (2011) DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev 25(8)801-13 (PubMed)

DYRK1A Gene Information

HGNC symbol
DYRK1A 
Aliases
DYRK; DYRK1; MNBH 
Common name
dual specificity tyrosine phosphorylation regulated kinase 1A 
Entrez Id
1859
Description
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008].

DYRK1A Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:18108; peptidyl-tyrosine phosphorylation
GO:46777; protein autophosphorylation
GO:7623; circadian rhythm
GO:45893; positive regulation of transcription, DNA-templated
GO:18105; peptidyl-serine phosphorylation
GO:18107; peptidyl-threonine phosphorylation
GO:7399; nervous system development
GO:43518; negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:31115; negative regulation of microtubule polymerization
GO:36289; peptidyl-serine autophosphorylation
GO:34205; amyloid-beta formation
GO:33120; positive regulation of RNA splicing
GO:38083; peptidyl-tyrosine autophosphorylation
GO:90312; positive regulation of protein deacetylation
GO:48025; negative regulation of mRNA splicing, via spliceosome
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5874; microtubule
GO:5856; cytoskeleton
GO:30424; axon
GO:30425; dendrite
GO:5883; neurofilament
GO:5884; actin filament
GO:1990904; ribonucleoprotein complex
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:48156; tau protein binding
GO:43621; protein self-association
GO:50321; tau-protein kinase activity
GO:3779; actin binding
GO:15631; tubulin binding
GO:4715; non-membrane spanning protein tyrosine kinase activity
GO:8092; cytoskeletal protein binding
GO:42802; identical protein binding
Hide GO terms

Homologs of DYRK1A in Model Organisms

Danio rerio
dyrk1ab
Drosophila melanogaster
mnb
Mus musculus
Dyrk1a
Rattus norvegicus
Dyrk1a
Schizosaccharomyces pombe
ppk15

External links

OMIM
600855
Ensembl
ENSG00000157540
Entrez Gene
1859
UniGene
368240
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DYRK1A
GeneCards
DYRK1A