Cell Senescence Entries for E2F3

Cell Types
Melanoma
Cell Lines
A2058, MeWo
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Noguchi et al. (2012) Anti-oncogenic microRNA-203 induces senescence by targeting E2F3 protein in human melanoma cells. J Biol Chem 287(15)11769-77 (PubMed)

E2F3 Gene Information

HGNC symbol
E2F3 
Aliases
 
Common name
E2F transcription factor 3 
Entrez Id
1871
Description
This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].

E2F3 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6606; protein import into nucleus
GO:82; G1/S transition of mitotic cell cycle
GO:6367; transcription initiation from RNA polymerase II promoter
GO:8284; positive regulation of cell population proliferation
GO:45893; positive regulation of transcription, DNA-templated
GO:70345; negative regulation of fat cell proliferation
GO:1905461; positive regulation of vascular associated smooth muscle cell apoptotic process
Cellular component: GO:5634; nucleus
GO:5667; transcription regulator complex
GO:785; chromatin
GO:5654; nucleoplasm
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1216; DNA-binding transcription activator activity
GO:3700; DNA-binding transcription factor activity
Hide GO terms

Homologs of E2F3 in Model Organisms

Danio rerio
zgc:158604
Mus musculus
E2f3
Rattus norvegicus
E2f3

External links

OMIM
600427
Ensembl
ENSG00000112242
Entrez Gene
1871
UniGene
703174
1000 Genomes
1000 Genomes
HPRD
GenAtlas
E2F3
GeneCards
E2F3