Cell Senescence Entries for E2F7

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, IMR-90, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Aksoy et al. (2012) The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence. Genes Dev 26(14)1546-57 (PubMed)

E2F7 Gene Information

HGNC symbol
E2F7 
Aliases
 
Common name
E2F transcription factor 7 
Entrez Id
144455
Description
E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008].

E2F7 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:8285; negative regulation of cell population proliferation
GO:1890; placenta development
GO:2040; sprouting angiogenesis
GO:32466; negative regulation of cytokinesis
GO:32877; positive regulation of DNA endoreduplication
GO:60707; trophoblast giant cell differentiation
GO:60718; chorionic trophoblast cell differentiation
GO:70365; hepatocyte differentiation
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:30330; DNA damage response, signal transduction by p53 class mediator
GO:71930; negative regulation of transcription involved in G1/S transition of mitotic cell cycle
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:5667; transcription regulator complex
GO:785; chromatin
GO:5654; nucleoplasm
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:1217; DNA-binding transcription repressor activity
GO:1990837; sequence-specific double-stranded DNA binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
Hide GO terms

Homologs of E2F7 in Model Organisms

Danio rerio
e2f7
Mus musculus
E2f7
Rattus norvegicus
E2f7

External links

OMIM
612046
Ensembl
ENSG00000165891
Entrez Gene
144455
UniGene
416375
1000 Genomes
1000 Genomes
HPRD
GenAtlas
E2F7
GeneCards
E2F7