Cell Senescence Entries for EGFR

Cell Types
Glioblastoma
Cell Lines
U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Liu et al. (2015) Berberine induces senescence of human glioblastoma cells by downregulating the EGFR-MEK-ERK signaling pathway. Mol Cancer Ther 14(2)355-63 (PubMed)

EGFR Gene Information

HGNC symbol
EGFR 
Aliases
ERBB; ERBB1; ERRP 
Common name
epidermal growth factor receptor 
Entrez Id
1956
Description
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020].

EGFR Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:165; MAPK cascade
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:7165; signal transduction
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1934; positive regulation of protein phosphorylation
GO:46718; viral entry into host cell
GO:1503; ossification
GO:98609; cell-cell adhesion
And 60 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:32991; protein-containing complex
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5886; plasma membrane
GO:5768; endosome
GO:5576; extracellular region
And 22 more GO terms
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:31625; ubiquitin protein ligase binding
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5515; protein binding
GO:4709; MAP kinase kinase kinase activity
And 15 more GO terms
Show all GO terms

Homologs of EGFR in Model Organisms

Mus musculus
Egfr
Rattus norvegicus
Egfr

In other databases

GenAge human genes
  • This gene is present as EGFR
LongevityMap
  • This gene is present as EGFR

External links

OMIM
131550
Ensembl
ENSG00000146648
Entrez Gene
1956
UniGene
605083
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EGFR
GeneCards
EGFR