Cell Senescence Entries for EGFR

Cell Types
Glioblastoma
Cell Lines
U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Liu et al. (2015) Berberine induces senescence of human glioblastoma cells by downregulating the EGFR-MEK-ERK signaling pathway. Mol Cancer Ther 14(2)355-63 (PubMed)

EGFR Gene Information

HGNC symbol
EGFR 
Aliases
ERBB; ERBB1; ERRP 
Common name
epidermal growth factor receptor 
Entrez Id
1956
Description
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020].

EGFR Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:165; MAPK cascade
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:7165; signal transduction
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1934; positive regulation of protein phosphorylation
GO:46718; viral entry into host cell
GO:1503; ossification
GO:98609; cell-cell adhesion
GO:45739; positive regulation of DNA repair
GO:46777; protein autophosphorylation
GO:42327; positive regulation of phosphorylation
GO:30154; cell differentiation
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:8284; positive regulation of cell population proliferation
GO:30335; positive regulation of cell migration
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:51897; positive regulation of protein kinase B signaling
GO:7173; epidermal growth factor receptor signaling pathway
GO:30307; positive regulation of cell growth
GO:42177; negative regulation of protein catabolic process
GO:45740; positive regulation of DNA replication
GO:34614; cellular response to reactive oxygen species
GO:45893; positive regulation of transcription, DNA-templated
GO:71276; cellular response to cadmium ion
GO:33674; positive regulation of kinase activity
GO:50679; positive regulation of epithelial cell proliferation
GO:51205; protein insertion into membrane
GO:71364; cellular response to epidermal growth factor stimulus
GO:71392; cellular response to estradiol stimulus
GO:1901224; positive regulation of NIK/NF-kappaB signaling
GO:43406; positive regulation of MAP kinase activity
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:18108; peptidyl-tyrosine phosphorylation
GO:38083; peptidyl-tyrosine autophosphorylation
GO:7166; cell surface receptor signaling pathway
GO:7202; activation of phospholipase C activity
GO:7611; learning or memory
GO:10750; positive regulation of nitric oxide mediated signal transduction
GO:14066; regulation of phosphatidylinositol 3-kinase signaling
GO:42059; negative regulation of epidermal growth factor receptor signaling pathway
GO:43006; activation of phospholipase A2 activity by calcium-mediated signaling
GO:45737; positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:46328; regulation of JNK cascade
GO:50730; regulation of peptidyl-tyrosine phosphorylation
GO:50999; regulation of nitric-oxide synthase activity
GO:70141; response to UV-A
GO:70372; regulation of ERK1 and ERK2 cascade
GO:1900020; positive regulation of protein kinase C activity
GO:1900087; positive regulation of G1/S transition of mitotic cell cycle
GO:1903078; positive regulation of protein localization to plasma membrane
GO:1903800; positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905208; negative regulation of cardiocyte differentiation
GO:902; cell morphogenesis
GO:1892; embryonic placenta development
GO:1942; hair follicle development
GO:7435; salivary gland morphogenesis
GO:8544; epidermis development
GO:21795; cerebral cortex cell migration
GO:42127; regulation of cell population proliferation
GO:48146; positive regulation of fibroblast proliferation
GO:48546; digestive tract morphogenesis
GO:60571; morphogenesis of an epithelial fold
GO:61029; eyelid development in camera-type eye
GO:71230; cellular response to amino acid stimulus
GO:71363; cellular response to growth factor stimulus
GO:50896; response to stimulus
GO:6898; receptor-mediated endocytosis
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:32991; protein-containing complex
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5886; plasma membrane
GO:5768; endosome
GO:5576; extracellular region
GO:5925; focal adhesion
GO:5615; extracellular space
GO:45121; membrane raft
GO:139; Golgi membrane
GO:31965; nuclear membrane
GO:30054; cell junction
GO:10008; endosome membrane
GO:9986; cell surface
GO:31901; early endosome membrane
GO:5887; integral component of plasma membrane
GO:43235; receptor complex
GO:30669; clathrin-coated endocytic vesicle membrane
GO:97708; intracellular vesicle
GO:48471; perinuclear region of cytoplasm
GO:9925; basal plasma membrane
GO:32587; ruffle membrane
GO:16323; basolateral plasma membrane
GO:70435; Shc-EGFR complex
GO:97489; multivesicular body, internal vesicle lumen
GO:30139; endocytic vesicle
GO:98590; plasma membrane region
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:31625; ubiquitin protein ligase binding
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5515; protein binding
GO:4709; MAP kinase kinase kinase activity
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:51015; actin filament binding
GO:3682; chromatin binding
GO:45296; cadherin binding
GO:3690; double-stranded DNA binding
GO:19903; protein phosphatase binding
GO:1618; virus receptor activity
GO:19900; kinase binding
GO:30235; nitric-oxide synthase regulator activity
GO:4888; transmembrane signaling receptor activity
GO:5006; epidermal growth factor-activated receptor activity
GO:48408; epidermal growth factor binding
GO:51117; ATPase binding
Hide GO terms

Homologs of EGFR in Model Organisms

Mus musculus
Egfr
Rattus norvegicus
Egfr

In other databases

GenAge human genes
  • This gene is present as EGFR
LongevityMap
  • This gene is present as EGFR

External links

OMIM
131550
Ensembl
ENSG00000146648
Entrez Gene
1956
UniGene
605083
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EGFR
GeneCards
EGFR