Cell Senescence Entries for EGR2

Cell Types
Mammary epithelial
Cell Lines
IMR-90, Primary cell, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Tyler et al. (2021) Early growth response 2 (EGR2) is a novel regulator of the senescence programme. Aging Cell 20(3)e13318 (PubMed)

EGR2 Gene Information

HGNC symbol
EGR2 
Aliases
KROX20 
Common name
early growth response 2 
Entrez Id
1959
Description
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].

EGR2 Ontologies

Gene Ontology
Process: GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:16925; protein sumoylation
GO:6357; regulation of transcription by RNA polymerase II
GO:7420; brain development
GO:7422; peripheral nervous system development
GO:6611; protein export from nucleus
GO:45444; fat cell differentiation
GO:35914; skeletal muscle cell differentiation
GO:31643; positive regulation of myelination
GO:6355; regulation of transcription, DNA-templated
GO:7611; learning or memory
GO:7622; rhythmic behavior
GO:8045; motor neuron axon guidance
GO:10467; gene expression
GO:14037; Schwann cell differentiation
GO:14040; positive regulation of Schwann cell differentiation
GO:21569; rhombomere 3 development
GO:21612; facial nerve structural organization
GO:21659; rhombomere 3 structural organization
GO:21660; rhombomere 3 formation
GO:21665; rhombomere 5 structural organization
GO:21666; rhombomere 5 formation
GO:30278; regulation of ossification
GO:32868; response to insulin
GO:35284; brain segmentation
GO:35904; aorta development
GO:42552; myelination
GO:48168; regulation of neuronal synaptic plasticity
GO:71310; cellular response to organic substance
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:785; chromatin
Function: GO:46872; metal ion binding
GO:16740; transferase activity
GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:3682; chromatin binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:61665; SUMO ligase activity
GO:71837; HMG box domain binding
Hide GO terms

Homologs of EGR2 in Model Organisms

Danio rerio
egr2b
Mus musculus
Egr2
Rattus norvegicus
Egr2

External links

OMIM
129010
Ensembl
ENSG00000122877
Entrez Gene
1959
UniGene
1395
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EGR2
GeneCards
EGR2